The analytical report examines the methodological, organizational, legal, political and other aspects of regions’ and local communities’ resilience. The world’s best practices in this field such as establishing and functioning of safety regions in the Netherlands and local resilience forums in Great Britain are analyzed. Challenges and prospects for resilience of territorial communities and regions in Ukraine are identified. Recommendations for the formation of a comprehensive model for inter-agency cooperation and coordination in the areas of national security and resilience at the regional and local levels in Ukraine are proposed. Intended for experts, scientists, specialists in the field of national security, authorities, representatives of public organizations and individuals, all those interested in the development of national resilience. It may also be useful in drafting and adopting legal acts regulating relations in this field.