This analytical report examines the methodological, organizational, legal, political and other aspects of the resilience of regions and local communities. The authors discuss the world’s best practices such as the establishing and functioning of safety regions in the Netherlands and local resilience forums in Great Britain and identify challenges and prospects for the resilience of territorial communities and regions in Ukraine. The report includes recommendations for the formation of a comprehensive model for inter-agency cooperation and coordination in the areas of national security and resilience at the regional and local levels in Ukraine. The information contained is intended for experts, researchers and specialists in the field of national security, officials, civil activists and all those interested in building up national resilience. It may also be useful in drafting and adopting legal acts regulating relations in this field.